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Hair Loss Research Studies By Inhairit

Research proves Inhairit is a natural DHT blocker
There exists a pharmacological cornucopia of herbs related to hair restoration and growth. Years of meticulous research and exhaustive testing has resulted in Inhairit’s unique DHT-blocking formula.

Follicular deterioration
Follicular deterioration is now widely recognized by doctors to be the main culprit behind more than 90% of female and male pattern baldness.

The deterioration occurs when an enzyme, 5-alpha reductase, converts testosterone to dihydrotestosterone (DHT) and causes a gradual, progressive shrinkage in the length and caliber of hair follicles. Follicular susceptibility to the hormone DHT is passed on genetically from either parent.

Inhairit’s natural ingredients block the effects of DHT
The proprietary blend of natural ingredients in Inhairit is proven to block the effects of DHT on the hair follicle, making it an effective female and male hair loss treatment. In addition to being a DHT Blocker, Inhairit restores the scalp so that healthy hair can grow.
Safety and Efficacy—the science behind Inhairit
Each natural ingredient in Inhairit’s Natural Hair Loss Solution has been studied and tested to create a formula that is highly effective in stopping hair loss and promoting hair growth in both men and women.

Product testing by Bodycote and Labs Mart

Inhairit’s DHT blocking liquid solution was extensively tested in two laboratories for the presence of materials heavy metal, mold, yeast, E Coli and passed.

Research on individual natural ingredients was carried out by the Medical Botany Research Group.

Additional references for our natural ingredients with regards to their effect on hair.
Reference: J Cosmet Dermatol. 2007 Jun;6(2):108-12.Development and evaluation of polyherbal formulation for hair growth-promoting activity.
Roy RK, Thakur M, Dixit VK.

Reference: Phytother Res. 2003 Apr;17(4):420-1.

Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.
Syed SD, Deepak M, Yogisha S, Chandrashekar AP, Muddarachappa KA, D'Souza P, Agarwal A, Venkataraman BV.

Reference: Planta Med. 1986 Oct;52(5):374-7. In Vitro 5-Lipoxygenase Inhibition by Eclipta alba Extracts and the Coumestan Derivative Wedelolactone

Wagner H, Fessler B.

Reference: Dev Dyn. 1997 Apr;208(4):553-64. Trypsin-induced follicular papilla apoptosis results in delayed hair growth and pigmentation.

Seiberg M, Wisniewski S, Cauwenbergh G, Shapiro SS.

Reference: Biochem Pharmacol. 1999 Sep 1;58(5):759-65.

Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships.
Kim HK, Cheon BS, Kim YH, Kim SY, Kim HP

Reference: Inflamm Res. 2003 Jun;52(6):227-9. Nitric oxide donors as potential additions to anti-alopecia areata armamentarium.

Namazi MR.

Reference: Journal of Ethnopharmacology, Vol. 102, Issue 1, 31 October 2005, Pages 23-31 Neuropharmacological profile of Eclipta alba (Linn.) Hassk

V.D. Thakur and S.A. Mengi

Reference: Planta Med. 1986 Oct;(5):374-7.

Wagner H, Fessler B.

Reference: J. Org. Chem., 68 (22), 8500 -8504, 2003.

Total Synthesis of Wedelolactone
Chuang Chuang Li,  Zhi Xiang Xie, Yan Dong Zhang, Jia Hua Chen, and Zhen Yang
Reference: J Altern Complement Med. 2002 Apr;8(2):143-52. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia
Prager N, Bickett K, French N, Marcovici G.

Reference: Prostate. 1998 Oct 1;37(2):77-83. Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia.

Di Silverio F, Monti S, Sciarra A, Varasano PA, Martini C, Lanzara S, D'Eramo G, Di Nicola S, Toscano V.

Reference: J Steroid Biochem. 1984 Jan;20(1):515-9. Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts.

Sultan C, Terraza A, Devillier C, Carilla E, Briley M, Loire C, Descomps B.

Reference: J Steroid Biochem Mol Biol. 1993 Feb;44(2):121-31. Azasteroids as inhibitors of testosterone 5 alpha-reductase in mammalian skin.

Mellin TN, Busch RD, Rasmusson GH.

Reference: Pediatr Res. 1980 Jan;14(1):67-9. Androgen receptors and metabolism in cultured human fetal fibroblasts.

Sultan C, Migeon BR, Rothwell SW, Maes M, Zerhouni N, Migeon CJ.

Reference: J Altern Complement Med. 2002 Apr;8(2):143-52. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia

Prager N, Bickett K, French N, Marcovici G.   

Reference: Clin Endocrinol (Oxf). 1993 Dec;39(6):633-9. Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells.

Thornton MJ, Laing I, Hamada K, Messenger AG, Randall VA.

EQUISETUM arvense - Horsetail 

Reference: British Journal of Dermatology Volume 126 Issue 5, Pages 479 - 484
Glycosaminoglycan synthesis by cultured human hair follicle dermal papilla cells: comparison with non-follicular dermal fibroblasts

Reference: J Invest Dermatol. 1992 Oct;99(4):386-9.

Topography of proteoglycan and glycosaminoglycan free chain expression in 3T3 fibroblasts and human keratinocytes.
Piepkorn M, Hovingh P, Linker A.

Reference: Am J Clin Dermatol. 2007;8(4):201-19.

Dermatologic manifestations of polycystic ovary syndrome.
Lee AT, Zane LT.

Reference: J Endocrinol. 1992 Jun;133(3):467-75. Localization of androgen receptors in human skin by immunohistochemistry: implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands.

Choudhry R, Hodgins MB, Van der Kwast TH, Brinkmann AO, Boersma WJ.


Reference: Journal of Investigative Dermatology (1989) 92, 725–726; Subcutaneous Blood Flow in Early Male Pattern Baldness

Per Klemp, Kurt Peters and Birgitte Hansted

Reference: Journal of Investigative Dermatology (2006) 126, 1937–1947. Neuropeptide Control Mechanisms in Cutaneous Biology: Physiological and Clinical Significance

Eva M J Peters, Marna E Ericson, Junichi Hosoi, Kristina Seiffert, Maria K Hordinsky, John C Ansel, Ralf Paus and Thomas E Scholzen

Reference: Arch Dermatol. 2003 Nov;139(11):1479-88.   Modern aspects of cutaneous neurogenic inflammation.

Steinhoff M, Ständer S, Seeliger S, Ansel JC, Schmelz M, Luger T.

Reference: Somatosens Mot Res. 1992;9(3):235-44. The sensory effects of l-menthol on human skin.

Green BG

Reference: J Investig Dermatol Symp Proc. 1997 Aug;2(1):61-8. Neural mechanisms of hair growth control.

Paus R, Peters EM, Eichmüller S, Botchkarev VA.


Reference: Growth Horm IGF Res. 2007 Oct;17(5):408-15. Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia

Harada N, Okajima K, Arai M, Kurihara H, Nakagata N.

Reference: Exp Dermatol. 2004 Mar;13(3):129-39. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures.

Ständer S, Moormann C, Schumacher M, Buddenkotte J, Artuc M, Shpacovitch V, Brzoska T, Lippert U, Henz BM, Luger TA, Metze D, Steinhoff M.

Reference: Growth Horm IGF Res. 2007 Apr;17(2):171-6. Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans

Harada N, Okajima K.

Reference: Kidney Int. 1995 Jul;48(1):45-51. Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen.

Feld SM, Hirschberg R, Artishevsky A, Nast C, Adler SG.

Reference: Growth Horm IGF Res. 2008 Feb;18(1):75-81.     Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats

Harada N, Okajima K.


Reference:  Dermatology. 1998;196(1):21-31. The human sebocyte culture model provides new insights into development and management of seborrhoea and acne.
Zouboulis CC, Xia L, Akamatsu H, Seltmann H, Fritsch M, Hornemann S, Rühl R, Chen W, Nau H, Orfanos CE.

Reference: J Clin Endocrinol Metab. 2008 Nov;93(11):4381-8. Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation.

van Beek N, Bodó E, Kromminga A, Gáspár E, Meyer K, Zmijewski MA, Slominski A, Wenzel BE, Paus R.

Reference: PNAS August 5, 1997 vol. 94 no. 16 8527-8532 The product of a thyroid hormone-responsive gene interacts with thyroid hormone  receptors

Catherine C. Thompson and Margaret C. Bottcher.

Reference: J Biol Chem. 1995 Dec 22;270(51):30651-6. Thyroid hormones stabilize acetylcholinesterase mRNA in neuro-2A cells that overexpress the beta 1 thyroid receptor.

Puymirat J, Etongue-Mayer P, Dussault JH.

Reference: Study of the effects of thyroid hormone on hair cycle and hair growth.

Yang Shuxia, Ma Shengqing, Qin Jian. First Hospital

Reference: Thyroid. 2001 Aug;11(8):717-24. Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats.

Safer JD, Fraser LM, Ray S, Holick MF.

OCIMUM Sanctum – Holy Basil

Reference: Biochem Biophys Res Commun. 2004 Jul 23;320(2):402-8. Effects of ursolic acid on different steps of the angiogenic process.
Cárdenas C, Quesada AR, Medina MA.

Reference: Free radical research, 2007-Jun; vol 41 (issue 6) : pp 638-44 Ursolic acid regulates high glucose-induced apoptosis

Oh, Chang Joo (CJ); Kil, In Sup (IS); Park, Chan Ik (CI); Yang, Chae Ha (CH); Park, Jeen-Woo (JW);

References: Biochimica et Biophysica Acta (BBA) Vol. 1760, Issue 10, October 2006, Pg 1505-12 Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake

Wei Zhan, Di Hong, Yueyang Zhou, Yinan Zhang, Qiang She, Jing-ya Li, Li-hong Hu, and Jia Li

Reference: J Pharmacol Exp Ther. 2001 Jan;296(1):181-7. Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages.

Xagorari A, Papapetropoulos A, Mauromatis A, Economou M, Fotsis T, Roussos C.

Reference: Mol Cancer Res. 2007 Sep;5(9):943-55.             Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.

Pathak AK, Bhutani M, Nair AS, Ahn KS, Chakraborty A, Kadara H, Guha S, Sethi G, Aggarwal BB.

Reference: Hormone Research Vol. 54, No. 5-6, 2000  

Liposomal Ursolic Acid (Merotaine) Increases Ceramides and Collagen in Human Skin
Daniel B. Yarosh, Dawn Both, David Brown

Reference:  J of Nutritional & Environ Medicine, Vol. 7, No. 2, 1 June 1997, pp. 113-118(6) Effect of Ocimum sanctum Leaf Powder on Blood Lipoproteins, Glycated Proteins and Total Amino Acids in Patients with Non-insulin-dependent Diabetes Mellitus.

Rai, V.; Ficn, U. V. Mani Msc Phd; Iyer, U.M.

Reference: J. Nat. Prod., 70 (9), 1410–1416Constituents of Ocimum sanctum with Antistress Activity 

Prasoon Gupta, Dinesh Kumar Yadav, Kiran Babu Siripurapu,  Guatam Palit, and Rakesh Maurya


Reference: Phytother Res. 2004 Sep;18(9):737-41. Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit.
Na M, Bae K, Kang SS, Min BS, Yoo JK, Kamiryo Y, Senoo Y, Yokoo S, Miwa N

Reference: Mol Cell Biochem. 2005 Sep;277(1-2):43-8.

Radiation protection by Terminalia chebula: some mechanistic aspects.
Gandhi NM, Nair CK.

Reference: Indian-J-Med-Sci. 1989 May; 43(5): 113-7 Screening of in vitro antibacterial activity of Terminalia chebula, Eclapta alba and Ocimum sanctum.

Phadke, S A : Kulkarni, S D

Reference: BMC Complement Altern Med 2006 May 7; 6(1):17. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats.

Koteswara Rao N, Nammi S

Before After
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Inhairit Natural Solutions Ltd.
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